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According to the results of a recent meta-analysis, NAC was moderately effective in relieving depression symptoms in adults with MDD, bipolar disorder, and other psychiatric conditions (43, 44)

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Using targeted LC-MS analysis of amino acids and acylcarnitines, increased arginine and ornithine levels were confirmed in BMDMs upon AC engulfment in vitro [86]

Some evidence suggests that MAOI therapy may be effective in patients with early-stage treatment-resistant depression (up to 3 prior antidepressant trials).35 In elderly patients with treatment-resistant depression who had failed tricyclic antidepressant (TCA) or venlafaxine extended-release treatment, a population with many comorbid conditions, remission was not achieved in any patient switched to phenelzine but was achieved by one-third of patients augmented with lithium.36 Tolerance of both treatments was very good considering the patients health status and demands for other medications