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345 Moreover, periodontitis has been reported to be closely associated with IBD

doi: 10.1016/j.abb.2019.07.024 52 PoloczanskaE

These familial forms are linked to mutations in over 20 genes, most notably C9ORF72, Cu/Zn superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma, many of which converge on pathways critical for RNA metabolism and protein homeostasis [310,313]