what if glutathione s transferase impaired P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution Glutathione transferases: substrates, inihibitors and

2004 Mar;30(2):135139

Importantly, since both glutamate export and cysteine import via system XcT are tightly linked to ferroptosis regulation, changes in glutamate or cysteine availability resulting from altered 5-OP metabolism could significantly impact cellular susceptibility to oxidative stress (Figure 3E)

Trends Pharmacol Sci 6 (FEST suppl):S15-S20 Pisani DE, Elliott AJ, Hinman DR, Aaronson LM, Pardini RS (1986) Relationship between inhibition of mitochondrial respiration by naphthoquinones, their antitumor activity, and their redox potential

These components are identified as the primary phytochemicals responsible for the pharmacological effects, including antioxidative, anti-inflammatory, antifatigue, and anticancer activity [98, 137]