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The regulation of HIFs is just one example of how ROS and cellular ratios of various TCA cycle metabolites, i.e., mitochondrial metabolism, can control gene expression and cellular responses (39)

J Am Coll Cardiol 29(5):10671073 Erbs S et al (2010) Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function