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Yuan Zhang, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

5.2.2 Tetramethylpyrazine Tetramethylpyrazine (TMP) is an active compound extracted from the rhizome of the Chinese herb Ligusticum chuanxiong, which has strong antioxidant properties and improvement of brain circulation and other pharmacological effects