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doi: 10.1128/mBio.02249-20 41

10.3390/cells12010090 435 SunZ.TangZ.YangX.LiuQ

One class of genes, informational genes (genes primarily involved in translation, transcription, replication, etc.), is a deeply diverging lineage which has been transferred in a tree-like pattern

In the case of GLYII proteins, two different subfamilies were observed in the phylogenetic tree, those with conserved active site motifs and therefore, enzymatically active and the other comprising of proteins which did not show conservation of active site residues