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Indeed, there is evidence about neutrophil chemoattractant cytokines [C-X-C motif chemokine ligand 1 (CXCL1) and CXCL5)] release by ECs but not in the context of COPD even if they are dysregulated in COPD patients [60, 61]

Such unwanted side effects include undesired tachycardia, increased lactic acidosis, cardiac arrhythmias (including atrial fibrillation) as well as the development of refractory shock (DeBacker et al, 2010

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This is why I believe combining anabolic support with GLP-1 therapy is not just beneficial but essential for optimal outcomes