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While GLP-1 receptors are present in the kidneys and may have mild natriuretic effects, they do not typically cause clinically significant polyuria (excessive urination) in the way that diuretic medications do

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Additionally, we decided to evaluate the activity of a synthetic analogue of the LL-37 peptide, namely the WLBU2 peptide (RRWVRRVRRWVRRVVRVVRRWVRR), consisting mainly of Arg (13 residues) and Val (8 residues), with 3 Trp residues on the hydrophobic side, separated by at least 7 amino acids to optimize its activity in blood (Deslouches et al., 2005), and the VFR12 (VFRLKKWIQKVI) peptide, which is derived from thrombin, taking into account the fact that coagulation disorders occur in sepsis (Kasetty et al., 2011) and it can be assumed that its concentration increases with sepsis development

"Best" is not established, because head-to-head human data does not exist