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Genetic abnormalities in Band 3, as observed in hereditary spherocytosis and Southeast Asian ovalocytosis, result in morphologically abnormal cells characterized by reduced flexibility and shortened life span due to increased splenic clearance (1)

These lesions are difficult and sometimes impossible to routinely resect without causing any significant damage to surrounding nerves and tissue

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However, the combination of GTP and NSAIDs was less effective than NSAIDs alone, potentially due to the heat released from GTP interfering with pain relief in patients experiencing heat pain