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Citrate produced in the cycle is exported to the cytoplasm and cleaved into acetyl-CoA and oxaloacetate, supplying essential precursors for the synthesis of lipids, amino acids, and other substances

Brief Bioinform 22:bbaa153 Alas M, Saghaeidehkordi A, Kaur K (2020) Peptidedrug conjugates with different linkers for cancer therapy

The third counter is the opportunity-cost argument

DSIP is widely studied in peptide neurobiology due to its ability to influence hypothalamic function, monoaminergic pathways, and circadian rhythm regulation