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The results of these in vitro studies suggest that elevated ROS facilitates the replication process in an array of viruses, including coronaviruses, especially in G6PD-deficient cells where the level of ROS is dysregulated [6, 38, 41, 42]

ACN acetonitrile AcOH acetic acid Acp-OH 4-(2-aminoethyl)-1-carboxymethyl-piperazine Ado 8-amino-3,6-dioxa-octanoic acid Boc t-butyloxycarbonyl DBU1,3-diazabicyclo[5.4.0]undecene DCC N,N-dicyclohexyl carbodiimide DCM dichloromethane DIPEA diisopropylethylamine DMAP dimethylamino-pyridine DMF N,N-dimethylformamide DMSO dimethylsulfoxide EDC 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid EDTA ethylenediaminetetraacetic acid eq stoichiometric equivalent Fmoc 9-fluorenylmethoxycarbonyl HATU O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyluronium hexafluorophosphate HFIP hexafluoroisopropanol HOBt N-hydroxybenzotriazole IS internal standard LCMS mass spectrometry-coupled liquid chromatography Lys lysine Mal 3-maleimido propionyl Mal-PEG6-NHS N-(3-maleimidopropyl)-21-amino-4,7,10,13,16,19-hexaoxa-heneicosanoic acid NHS ester MHA 6-mercaptohexanoic acid Mmt 4-methoxytrityl MS mass spectrum MW molecular mass n.d

This disease burden can significantly impair health-related quality of life [2]

In a subset of patients recovered from COVID-19, long-term dysbiosis correlated with PASC symptoms, especially fatigue, joint pain, diarrhea, headache, depression, and anxiety 246