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doi: 10.4172/2153-0645.1000141 149 KozlovE

Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes 6

In thiol-oxidoreductases as thioredoxins (Trxs) and glutaredoxins (Grxs), the lowering of the pKa results from the protein microenvironment as these thiolates are stabilized by proximal positively charged amino acids, by specific hydrogen bonding and/or by a dipole effect induced at the N-terminus of an -helix