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doi: 10.1016/j.heliyon.2024.e31895 377 SabuMCSmithaKRamadasanK

This approach provides both the systemic gene expression modulation from injections and concentrated local delivery from topical application

PKC activation disrupts normal metabolism, leading to ATPase phosphorylation and metabolic disorders, including changes in VEGF and vasoconstriction, which affect pain perception

Testing should include: Comprehensive metabolic panel Gamma-glutamyltransferase if alcohol abuse is suspected, since heavy alcohol use is one of the most common causes of both large and small fiber neuropathy