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In addition, we noted the upregulation of the nuclear importer protein KPNA2 that is targeted by the SARSCoV2 protein ORF6 resulting in nuclear exclusion of STAT1, thereby preventing antiviral signaling (Miyamoto et al , 2022)

Drop your shoulders and unclench your jaw (oddly effective)

An alternative screening method is the determination of the ability to induce proliferation of cells involved in immune responses, such as B cells, T cells, monocytes/macrophages, total PBL, and the like