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In addition, under oxidative stimuli, p53 upregulates the downstream gene TP53-induced glycolysis and apoptosis regulator (TIGAR) to promote the conversion of the glycolysis pathway to the pentose phosphate pathway, thereby enhancing nicotinamide adenine dinucleotide phosphate (NADPH) production to counteract ROS

doi:10.1021/acsmedchemlett.1c00694

It has FDA approval

Antioxidants can effectively eliminate free radicals and play a crucial role in preventing and treating many age-related diseases (Shields et al., 2021