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However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination

No elevation of IGF-1, no glucose metabolism disruption, no fluid retention, no anti-peptide antibody formation, no serious adverse events attributable to the compound

Adult male C57BL/6 mice on a 60% kcal-from-fat high-fat diet received intraperitoneal or oral 5-Amino-1MQ at amounts in the milligram-per-kilogram range or vehicle, over an 11-day treatment period in the published protocol