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At the same time, the number of senescent cells, associated with damage or stress that secretes proinflammatory factors (SASP or senescence-associated secretory phenotype), increases with age in many key tissues, including the kidneys, lungs, blood vessels, and brain SAM may not get the same level of media attention as NAD+, but that doesnt stop it from being less useful: S-adenosylmethionine, or SAM, has been used for several years in the treatment of hepatic conditions and osteoarthritis and more recently in the treatment of clinical depression

HUBERMAN: And that you get these compounds from a quality compounding pharmacy or by their name brand prescription

It is knowing where to look and which mechanism fits your technology, your stage, and your goals

It modulates neurotransmitter levels such as gamma-aminobutyric acid (GABA) and serotonin, which are critical in inducing and maintaining sleep over an extended period