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Although elevated levels of the enzyme PDXK, which helps in the conversion of pyridoxine, the precursor to vitamin B6, into pyridoxal-5-phosphate, the bioactive form of vitamin B6, have also been related to an increased risk of colorectal cancer developed plasma homocysteine levels have been linked as well with an increased risk of non-small cell lung carcinoma (168, 169)

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As illustrated in Figure 2, substantial translational gaps remain between promising preclinical synergy and implementation in human aging contexts