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70,71 Gerin et al established a septic lung injury model by cecum ligation and puncture in rats, showing that early administration of Quercetin reduced the levels of oxidative stress markers, such as xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA), and increased the levels of antioxidant enzymes in lung tissues, leading to a reduction in oxidative stress and consequently reduced production of inflammatory factors in the lungs

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59 When activated after physical contact with tumour cells, microglia promote the accumulation in these cells of ROS, leading to ROS-induced apoptosis or other oxidative damage as an immune defence