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Likewise, its easy applicability during the course of an injurys treatment might bypass the limitation of the standard agents (for review, see [1,3,4,5,6,8,9,32,33,34,92]) (i.e., the greater effect normally thought to result from prevention than treatment [35,36,37,38,39,40,41,42])

The patients having factor XII (FXII) deficiency do not have a bleeding tendency and remain practically asymptomatic, although its dysregulation has been associated with hereditary angioedema, thrombosis, and neuroinflammation [8]