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As the dose climbs, the balance changes

Specifically, we treated in parallel groups of Tbx1 +/ mice with PBS (n = 14) or vB12 (n = 13) and compared them with a group of WT mice treated with PBS (n = 15) or vB12 (n = 18)

For those diagnosed with Wernickes encephalopathy it is recommended to receive thiamine doses of 200 500mg three times daily for 3 5 days followed by oral thiamine doses ranging from 250 1000mg per day