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First-degree relatives of vitiligo patients have a 68% risk of developing the disease, and the concordance rate between monozygotic twins is approximately 23%.28,34 Five genome-wide association studies (GWAS) have been conducted on vitiligo in European and Asian populations, identifying at least 54 vitiligo susceptibility loci.49,50 Human leukocyte antigen region Several genes within the human leukocyte antigen (HLA) region, specifically in class I and II regions, are associated with vitiligo

Mac Farquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C, Burk RF, Dunn JR, Green AL, Hammond R, Schaffner W, Jones TF

Estrogens and their selective receptor modulators have been shown to reduce the apoptosis, oxidative stress, mitochondrial membrane depolarization, and Ca 2+ influx of neurons (Yazan and Nazirolu, 2017