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As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure

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Insufficient intake The most common cause of vitamin B12 deficiency is insufficient intake (absorption), which can be caused by the following: excessive bacterial growth in the small intestine impaired absorption (malabsorption) due to coeliac disease [1] or a disease of the pancreas inflammatory diseases of the small intestine (vitamin B12 is absorbed in the small intestine) surgery on the gastrointestinal tract

Every batch is tested by a US-based analytical laboratory before release, including identity by mass spectrometry (LC-MS), purity by HPLC, and bacterial endotoxin screening (LAL)