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As expected, mice on a high-fructose diet were protected against APAP hepatotoxicity, but deletion of Chrebp resulted in increased necrosis and liver ROS as well as elevated serum ALT and LDH levels [53] , confirming that fructose protection against APAP hepatotoxicity is mediated through the ChREBP-FGF21 axis [53]

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Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis

Separation of cytochrome c-dependent caspase activation from thiol-disulfide redox change in cells lacking mitochondrial DNA