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doi: 10.1038/s41467-024-54861-3 325 SzuJITsigelnyIFWojcinskiAKesariS

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Subsequently, lipid peroxidation promoted the activation of IB kinase- (IKK)/NF-B, which further mediated chronic inflammation and impaired insulin signaling by inhibiting insulin-stimulated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) activities (53)