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Introduction Cardiovascular diseases (CVDs) are the leading cause of death worldwide and rising health care costs [1]

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Remien et al.[10] recently developed a mathematical model to estimate overdosage of APAP based on indicators of liver damage (blood levels of aspartate aminotransferase, alanine aminotransferase and the international normalized ratio of prothrombin time) that are measured upon admission to hospital emergency departments

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element