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The Center for Biologics Evaluation and Research (CBER) published three updated standard operating policy and procedures (SOPP) used by agency staff when reviewing products, including one on expediting the review of breakthrough therapies

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Thus, T4 has substantial potential for clinical translation as a multiple-target therapy for MS/EAE or other neurological demyelinating diseases, with the remyelination effect supplementing its anti-inflammatory and neuroprotective role, as previously found in studies involving T4 prophylactic treatment (Zhang et al., 2009)

For IM injections, a 22 to 25 gauge needle is typically used