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The loss of expression of some antioxidant enzymes could be used as biomarkers too such as catalase (CAT) and superoxide dismutase (SOD)

doi: 10.2174/1871530319666190930110605 56 WangZZhangQLuJJiangFZhangHGaoLet al

On the other hand, the NCI H23 cell line, sensitive to cisplatin, shows a mutation at the IVR (intervining-region) domain of KEAP1

Recent research has also shown that the intestinal flora and its metabolites may play a key role in the regulation of the immune system response and the development of autoimmune diseases, such as rheumatoid arthritis (RA) (Sun et al., 2019),multiple sclerosis (MS) (Cantoni et al., 2022), systemic lupus erythematosus(SLE) (Luo et al., 2018), type 1 diabetes(T1D) (Knip and Honkanen, 2017), and HT (Belvoncikova et al., 2022)