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Auranofin modulates ferritinophagy to induce ferroptosis in NB Ferritinophagy is a specific type of autophagy that can lead to iron overload and ferroptosis 62,63,64,65,66

This can be a problem when folate is limited.[ref][ref][ref] One copy of the C677T variant reduces enzyme function by about 35-40%

By contrast, P-gp-knockout cells (AuxB1 Pgp , CHO R C5 PgpA1 , and CHO R C5 PgpA3 ) were highly sensitive to colchicine and resistant to tamoxifen (Fig