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(2012) 46:S12

Several studies have shown that most patients with severe COVID-19 exhibit markedly increased concentrations of pro-inflammatory cytokines in their serum, including IFN-, IFN-, IL-1, IL-6, IL-12, IL-17, IL-18, IL-33, TNF-, G-CSF, GM-CSF, IP10, MCP1, MIP1, and C-reactive protein (CRP) [68, 69], suggesting a combination of the pre-existing pro-inflammatory status observed in older individuals with an additional virus-induced pro-inflammatory status