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As a result, most of the weight loss associated with phentermine comes from eating less, not necessarily from increased physical activity

Landmark studies on the origin of (excessive) thalamo-cortical burst firing revealed that the balance between inhibition and excitation in thalamo-cortical networks is effective in setting the firing pattern of thalamo-cortical relay neurons by controlling the activation of low-threshold voltage-gated Ca 2+ channels (as reviewed in ref [103])

Prophylactic supplementation may be considered for select high-risk patients, particularly those with strict vegan diets, post-bariatric surgery, or on long-term metformin therapy