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doi: 10.1210/jcem.83.4.4744 136 MaccarioMVeldhuisJDBroglioFVitoLDArvatEDeghenghiRet al

Role of NAD+ in regulating cellular and metabolic signaling pathways

Specifically, it produces no IGF-1 elevation (avoiding proliferative concerns), no negative impact on glucose metabolism (avoiding diabetes risk), no fluid retention or edema, and no concerning patterns of joint pain that can occur with growth hormone