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Impaired oxidative phosphorylation (OXPHOS), elevated reactive oxygen species (ROS) levels, and calcium dysregulation disrupt cellular energetics and extracellular matrix (ECM) homeostasis, contributing to the hallmark features of hEDS

Ascorbic acid has direct antioxidant effects, and also it is a substrate for the redox enzyme ascorbate peroxidase, that is particularly important in stress resistance in plants

Peroxisome biogenesis disorders (PBDs) have mainly genetic backgrounds and are caused by incorrect genesis, mainly their assembly, or functional defects of peroxisomes [109]