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Identifying at-risk individuals and treating them in a prodromal phase based on their driving pathophysiological process could prevent the manifestation of PD, or at least alter the disease progression (Ascherio and Schwarzschild, At present, two approaches could be feasible to investigate this matter: the a-priori stratification of study cohorts (based on assumed mitochondrial dysfunction) or the in-vivo assessment of mitochondrial dysfunction (by neuroimaging methods or blood biomarkers) (Prasuhn et al., 2019)

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These boys developed worsening aggression (including self-injurious behavior in one) within 2 weeks of starting leucovorin calcium, resulting in immediate discontinuation, making worsening aggression the most common AE of leucovorin calcium treatment