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2 Introduction Insomnia is defined as difficulty falling or staying asleep, dissatisfaction with sleep, and daytime impairment due to sleep loss

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doi: 10.1124/jpet.106.107185 32 WolosJAFrondorfKABabcockGFStrippSABowlinTL

Encapsulated within LNPs, these contaminants (e.g., fragments of plasmid cDNA coding for SV40) may integrate into the human genome, raising concerns about insertional mutagenesis, autoimmunity, and oncogenesis