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Simultaneously, there is an enhancement of the expression of heat shock proteins (e.g., HSP70 and HSP90) and antioxidant proteins (e.g., heme oxygenase (HO-1), NAD(P)H dehydrogenase (NQO-1), glutathione reductase, glutathione peroxidase 2, and glutathione S-transferase pi (GST-pi)) [18]

Many cancer cells adapt to stressful conditions by upregulating stress-buffering proteins such as glucose-regulated protein 78 (GRP78), 158 which dampens ER stress signaling, or activating nuclear factor erythroid 2related factor 2 (Nrf2)-mediated antioxidant pathways to suppress ROS accumulation, 159 thereby blunting DAMP release even in response to ICD-inducing agents

Cyanocobalamin stimulates haematopoietic processes, activates creatine synthesis, fat metabolism, and the biosynthesis of methionine and other metabolic processes

It has been hypothesized that the peptide may encourage the elongation of hair follicles and the proliferation of dermal papilla cells