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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

33 Furthermore, aberrant RNA modification patterns are integrated into the regulatory networks of other epigenetic mechanisms, such as histone deubiquitylation and DNA methylation, playing critical roles in nuclear reprogramming

Her teaching was recognized by funding from the Howard Hughes Medical Institutes Professor Program

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