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16,18 Early concerns about pancreatic safety arose from reports of pancreatitis in animal studies with the use of sitagliptin, clinical reports of humans treated with exenatide and the detection of preneoplastic pancreatic ductal lesions in animals treated with GLP-1 receptor agonists

More in-depth studies from the same group investigating which HDACs are responsible for such an effect showed that inhibition of both HDAC1 and HDAC3 is required for FXN activation, and only compounds targeting these particular class I HDACs are active in increasing FXN mRNA [43]

The Institutional Animal Care and Use Committee approved the use of animals for this study

Micheles podcast, Ageless and Timeless, was one of 20 Inaugural Podcasts selected for the Muscle and Fitness Plus platform that began in 2023