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For context, CagriSema's GI rate was compared to its individual components: semaglutide alone and cagrilintide alone both had lower GI event rates than the combination, consistent with additive GI effects

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Indirect evidence suggests that DBS of targets in the basal ganglia or the pedunculopontine nucleus may work best for PD if they involve pathways that connect to the cerebellum [164, 165], suggesting that some of the therapeutic effects of these interventions might involve the cerebellum