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In vitro experiments confirmed that SPY1 overexpression significantly activated the GCH1/BH4 signaling pathway in NSC-34 cells transfected with the human SOD1 G93A gene

Sharma E, Sharma R, Borah P, Jain M, Khurana JP

Animal model results RAPA-induced autophagy activation partially ameliorated MIA-induced behavioral abnormalities In the prepulse inhibition (PPI) test, MIA mice exhibited reduced startle inhibition at 70 and 80 dB prepulses (Fig