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doi: 10.1210/er.2005-9998 52 VermeulenEDHaensJStadnikTUnuaneDBarbeKVan VelthovenVet al

Because it carries two amine groups, it acts as a primary non-toxic transporter of ammonia in the blood, safely moving this metabolic waste product from peripheral tissues to the liver and kidneys for processing and excretion

This involves the activation of caspases, cysteine-aspartic proteases that orchestrate cell dismantling by cleaving specific substrates

Decreased ratios of product to precursor suggested a shift favorable to the Xant production resulting in decreased UA levels in the FENNS ( Figure 2 )