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SKU: 17034922357
Price: 26.24 USD
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Description

Biofabrication 12 , 32002 (2020)

Mechanistically, autoantibodies and interferon- present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREM to the glutathione peroxidase 4 ( Gpx4 , the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species

These observations highlight the presence of metabolic modifications within the MM niche that may facilitate immune evasion strategies ( The high level of ADO detected in the BM niche may contribute to the overall anergic state observed in MM patients