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Moreover, at this time point, the presence of MEL resulted in a greater increase in the expression level of most genes ( GSH1 , GPX1 , GLR1 , CTA1 , SOD1 , SOD2 , and GRX2) , between 3 and 5 times higher than under the control condition ( Figure 3 , inset)

Gene hallmark analysis showed increased expression of genes involved in endothelial to mesenchymal transition, NF-kB pathway and hypoxia in females, while increased expression in MYC targets, oxidative phosphorylation and mTOR pathway were reported in males (118)

Capsid precursor P1, in a complex with Hsp90, is processed by 3CD pro yielding mature viral proteins VP0, VP1 and VP3, which spontaneously form 5S protomer

HPCAL1 mediates the degradation of CDH2 and reduces plasma membrane tension to promote lipid peroxidation