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Description

Mechanistic insights were derived from transcriptomics and lipid peroxidation assays

The gap between the gene expression research (which suggests systemic biological effects) and the actual human evidence (which is limited to topical skin endpoints) is substantial

Ferroptosis regulates lipid peroxidation via the GPX4/acyl-CoA synthetase long chain family member 4 axis, and targeting of GSH metabolism selectively eliminates resistant subpopulations that are dependent on antioxidant defenses