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These amino acids combine with the metal copper to form a "signal" molecule

Notably, patients with pulmonary infections showed a 2.6-fold increased bleeding risk (20.72% vs 79.28% in non-infected patients), while proton pump inhibitor (PPI) coadministration was associated with a persistent 2.3-fold elevated bleeding risk throughout therapy (42.86% vs 19.05% in non-users)

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