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Enhancing fusion in pancreatic adenocarcinoma models, either via mitofusin 2 (MFN2) overexpression or DRP1 inhibition, paradoxically increased mitophagy, leading to reduced mitochondrial mass and OXPHOS capacity

In the context of limited glutamine, various cell components in the TME compete for glutamine, and tumor cells can increase their uptake of glutamine due to their unique metabolic mode, thus providing certain competitive advantages

Inappropriate p53 activation during development induces features of CHARGE syndrome

3.21).46 High doses of methionine increase urinary ex- cretion of calcium and should be avoided by Parkinson disease