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Importantly, growing evidence suggests relying solely on the number of infiltrating lymphocytes and plasma cells in the lamina propria may not be helpful, as more subtle, architectural changes of the mucosa might be more suited to grade the severity of disease 11,19

The TNM staging of our sample, on the other hand, was predominantly T3 and quite single, which could have had an impact on our analysis of how IGF-1 affects CRC