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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

Healthcare providers aim to reduce side effects while keeping the benefits high

The vasoprotective effects align neatly with the mechanistic picture: a compound that promotes angiogenesis and modulates nitric oxide would predictably stabilize vascular function across a range of stressors