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It exists as an active dimer 45 and targets phosphorylation of downstream targets such as CHK2, H2AX and p53 44,47,48,49

Moreover, RN is often indistinguishable from pseudoprogression and progression on imaging [91]

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While the first two hypotheses cannot be ruled out, we have shown the latter to occur spontaneously in vitro, in the absence of additional thiol-containing molecules