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Synthetic antibiotics have a speedy therapeutic impact when used to treat microbial infections, but they also represent a substantial risk of gastrointestinal and renal toxicity, and microbial resistance

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On the other hand, lipid-soluble antioxidants as vitamin E cross the BBB slowly and may require prolonged exposure to achieve meaningful brain concentrations, where none of the vitamin-based AMS trials assessed these agents reach the relevant target tissues, this evident limitation strongly constrains interpretation of clinical outcomes and underscores the PK-PD disconnect between theoretical neuroprotective effect and observed efficacy (Table 3)